The hypoglycemic and anti-diabetic effect of hydro-ethanolic extract of Helicteres isora Linn (Family-Sterculiaceae) root extracts (HIE) were investigated in normal and alloxan-induced di-abetic rats. In the present study, the animals were divided into normal control, diabetic control, diabetic treated and control treated group (n = 6). Effect of oral administration of HIE (300 mg/kg) for 30 days on the level of blood glucose, glycosylated hemoglobin (HbA1C), total cho-lesterol (TC), triglycerides (TG), phospholipids, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), hexokinase, lactate dehydrogenase (LDH) and glucose-6-phosphatase in normal and alloxan-induced diabetic rats were evaluated. When comparing the values of the HIE treated group with those of the control diabetic group, we found that the HIE significantly decreased the elevated blood glucose level, glycosylated hemoglobin, cholesterol, triglycerides, phospholipids, LDL, VLDL. It showed a significant increase in liver glycogen, insulin and HDL level. Treatment with HIE in diabetic rats increased the hexokinase, LDH activity and decreased the glucose-6-phosphatase activity. These results clearly indicated that HIE possess promising anti-diabetic effect in diabetic rats.
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